MOTS-c is a synthetic mitochondrial-derived peptide composed of 16 amino acids, encoded within mitochondrial DNA and involved in cellular metabolic regulation. It is commonly utilized in research settings to study energy homeostasis, metabolic signaling pathways, and mitochondrial function. Supplied by Peptico for research-use only.
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Format
Lyophilized powder
Approved Exclusively For
Laboratory and Analytical Research
Handling
Utilize appropriate sterile technique and controlled environments during preparation.
Short-Term Storage - Lyophilized Powder Form Only
- For maximum potency, lyophilized materials may generally be stored between 2°C and 8°C (36°F to 46°F) for up to 4 weeks when maintained in their original, sealed lyophilized form.
- Maintain a cool and dry environment.
- Protect from moisture and light.
- Minimize exposure to humidity and temperature fluctuations.
Long-Term Storage - Lyophilized Powder Form Only
- For maximum potency and long-term preservation, lyophilized materials may generally be stored between -20°C and -80°C (-4°F to -112°F) for up to 1 year when preserved in their original, sealed lyophilized form.
- Maintain a cool and dry environment.
- Protect from moisture and light.
- Minimize exposure to humidity and temperature fluctuations.
Important Note:
Storage guidelines apply only to lyophilized material in its original, sealed, and untampered vial.
COA History
All shipped products include a unique batch number printed on the vial label. This batch number corresponds to a third-party Certificate of Analysis tested by an ISO/IEC 17025 accredited laboratory.
The COA attached at the top of this page, along with the COA marked “Current” below, represents the active production batch currently being shipped. This same batch number will appear on the label of your vial.
For previous purchases, please refer to COAs marked “Historical” and match the batch number on your vial to the batch number listed on the corresponding COA.
For a complete record of testing documentation across all products and batches, please visit our COA Vault, which includes both current and historical COAs.
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Molecular Profile
What is MOTS-C?
Scientific compound data sourced from PubChem.
Chemical Structure
PubChem CID 146675088
Type
Peptide compound
PubChem CID
146675088
CAS Number
1627580-64-6
Molecular Formula
C101H152N28O22S2
Molecular Weight
2174.60 g/mol
IUPAC Name
(4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
InChIKey
WYTHCOXVWRKRAH-LOKRTKBUSA-N
Research
Sources & References
API results related to MOTS-C.
PubChem
Compound data
MOTS-C compound record
CID: 146675088
Formula: C101H152N28O22S2 • Molecular weight: 2174.6
View source
PubMed
Scientific paper
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming.
Bioactive materials
Publication date: 2027 Jan
View source
PubMed
Scientific paper
MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential.
European journal of pharmacology
Publication date: 2026 Oct 15
View source
PubMed
Scientific paper
MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation.
Autophagy
Publication date: 2026 Oct
View source
PubMed
Scientific paper
MOTS-c mediates remote ischemic preconditioning-induced protection against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis.
Chinese medical journal
Publication date: 2026 Sep 21
View source
PubMed
Scientific paper
Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications.
Journal of bioenergetics and biomembranes
Publication date: 2026 Sep 14
View source⚠️ IMPORTANT RESEARCH NOTICE
This product is NOT for human consumption.
Supplied strictly for laboratory and analytical research use only, it is not intended to diagnose, treat, cure, or prevent any disease, and must not be used for clinical, veterinary, or therapeutic applications.
All information provided, including referenced research and data, is for educational and scientific context only and should NOT be interpreted as medical guidance.
By purchasing, you confirm that you are a qualified individual or entity operating in accordance with applicable local, state, and federal regulations. All responsibility for handling, use, and compliance rests solely with the purchaser.